Subcortical and Deep Cortical Atrophy in Frontotemporal Dementia due to Granulin Mutations
نویسندگان
چکیده
منابع مشابه
Subcortical and Deep Cortical Atrophy in Frontotemporal Dementia due to Granulin Mutations
BACKGROUND/AIMS Parkinsonism is often associated with symptoms of frontotemporal dementia (FTD), but its pathogenesis has been largely neglected. In genetic inherited FTD-related granulin (GRN) mutations, parkinsonism is an early sign, and it is more common than in sporadic disorders. Our aim was to study grey matter (GM) volume changes in subcortical and deep cortical regions in GRN-related FT...
متن کاملComparative Study of Subcortical Atrophy in Patients with Frontotemporal Dementia and Dementia with Extrapyramidal Signs
OBJECTIVES To investigate the severity of subcortical atrophy in frontotemporal dementia (FTD) without extrapyramidal symptoms (EPS) and dementia with EPS. In addition, we aim to verify if there is correlation between demographic and clinical characteristics and subcortical atrophy in the groups. Methodology : The sample was composed of 21 patients with dementia and EPS as well as 19 patients w...
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F rontotemporal dementia (FTD) with amyotrophic lateral sclerosis (ALS) presents with impaired language or behavior and declining motor function. Frontotemporal lobar degeneration with ubiquinated transactivating responsive sequence DNAbinding protein (TDP-43) inclusions is found postmortem in the affected brain areas of patients with ALS, FTD/ ALS, and many patients with FTD. Prior magnetic re...
متن کاملSubcortical Atrophy in Cognitive Impairment and Dementia.
BACKGROUND Cortical atrophy is a key neuroimaging feature of dementia. However, the role of subcortical gray matter reduction in cognitive impairment has not been explored extensively. OBJECTIVES We examined the risk factors of subcortical structures on neuroimaging and their association with cognitive impairment and dementia. METHODS Data from two studies were used: a subsample from the Ep...
متن کاملPatterns of brain atrophy in frontotemporal dementia and semantic dementia.
OBJECTIVE To identify and compare the patterns of cerebral atrophy associated with two clinical variants of frontotemporal lobar degeneration (FTLD): frontotemporal dementia (FTD) and semantic dementia (SemD). METHODS Twenty patients with FTLD were classified as having FTD (N = 8) or SemD (N = 12) based on current clinical criteria. Both groups showed a similar spectrum of behavioral abnormal...
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ژورنال
عنوان ژورنال: Dementia and Geriatric Cognitive Disorders Extra
سال: 2014
ISSN: 1664-5464
DOI: 10.1159/000355428